The activation of CaN/NFAT signaling pathway in macrophages aggravated Lactobacillus casei cell wall extract-induced Kawasaki disease vasculitis.

Yameng Sun,Yijing Tao,Zhimin Geng,Fenglei Zheng,Ying Wang,Yujia Wang,Songling Fu,Wei Wang,Chunhong Xie,Yiying Zhang,Fangqi Gong

Cytokine（2023）

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摘要

Therefore, the CaN/NFAT signaling pathway mediated LCWE-induced immune responses in macrophages, and also participated in the LCWE-induced CALs(coronary artery lesions). And also the inhibitory effect of CsA in LCWE-induced cell model towards a strategy to modulate the CaN/NFAT pathway during the acute course of KD might be helpful in alleviate KD-induced CALs.

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关键词

Kawasaki disease,Immune coronary artery injury,Macrophage,Activated T cell nuclear factor,Calcineurin inhibitor

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