The relationship of maternal polymorphisms of genes related to meiosis and DNA damage repair with fetal chromosomal stability.

Ying Chan,Xinhua Tang,Dongling Cai,Yize Liu,Dongmei Li,Jie Su, Guowei Neng,Yifei Yin, Zibiao Geng,Shu Zhu,Jinman Zhang,Lihong Jiang,Baosheng Zhu

Journal of perinatal medicine（2023）

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摘要

For older women, maternal 1 rs2277339 and 1 rs10183486 polymorphisms may be associated with fetal aneuploidy, while rs4693089 may be associated with fetal chromosome structural abnormality. Also, carriers of T allele of 1 rs10183486 have a lower risk of fetal chromosome structural abnormality in younger women.

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关键词

maternal polymorphisms,dna damage repair,dna damage,meiosis,genes

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