Editorial: Discovery of digital biomarkers in the background of big data and advanced machine learning.

The concept of digital biomarkers is related to the machine learning application to physiology and 10 medicine, the latent features of a deep learning model could be regarded as a digital marker. Additionally, 11 it is anticipated that important added values will be extracted from convenient devices on a daily basis, 12 such as being more sensitive than a conventional intervention marker. Of note, considering the personal 13 difference that exists in almost all kinds of biosignals, a potential marker should be statistically significant.