Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway.

Ruosha Lai,Qiaojun Fang,Fan Wu,Song Pan, Khujista Haque,Su-Hua Sha

Frontiers in cellular neuroscience（2023）

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摘要

These results indicate that noise-induced calpain activation negatively regulates PI3K/Akt downstream signaling, and that prevention of NIHL by treatment with MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathways.

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关键词

prevention of noise-induced hearing loss, calpain inhibitor MDL-28170, PI3K, Akt signaling, alpha-fodrin, auditory sensory hair cells

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