Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases.

Mami Neishi,Hirofumi Hamano,Takahiro Niimura,Masaya Denda,Kenta Yagi,Koji Miyata,Tsung-Jen Lin,Tsukasa Higashionna,Mitsuhiro Goda,Yoshito Zamami,Keisuke Ishizawa,Hideki Nawa

Toxicology and applied pharmacology（2023）

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摘要

This study has confirmed using big data, that EPZ, the optical isomer and racemic form of omeprazole, has the beneficial characteristics of being less sensitive to CYP, as was intended by its design.

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关键词

Esomeprazole,Omeprazole,Adverse reactions,Japanese adverse drug event report database,FDA adverse event reporting system

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