Exaggerated amygdala response to threat and association with immune hyperactivity in depression

Sarah Boukezzi,Sara Costi,Lisa M. Shin,Seunghee Kim-Schulze,Flurin Cathomas,Abigail Collins,Scott J. Russo,Laurel S. Morris,James W. Murrough

Brain, Behavior, and Immunity（2022）

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摘要

•Amygdala response to threat is greater in individuals MDD compared to HC.•Immune response to LPS is associated with heightened amygdala response to threat.•Perceived stress predicts anxious arousal, inflammation and amygdala activation.

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关键词

Inflammation,Major depressive disorder,Threat,Anxious arousal,Amygdala,Leukocytes,Neuroimaging,Functional MRI,Stress

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