Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity.

Heather Lynn,Xiaoguang Sun,Nancy G Casanova,Christian Bime,Vivian Reyes Hernon, Clayton Lanham,Radu C Oita, Nikolas Ramos,Belinda Sun,Dawn K Coletta,Sara M Camp,Jason H Karnes,Nathan A Ellis,Joe G N Garcia

Therapeutic advances in respiratory disease（2023）

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摘要

SNPs influence promoter activity, eNAMPT protein expression/secretion, plasma eNAMPT levels, and ARDS severity. genotypes are a potential tool for stratification in eNAMPT-focused ARDS clinical trials.

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关键词

acute respiratory distress syndrome (ARDS), enzyme-linked immunosorbent assay, extracellular nicotinamide phosphoribosyltransferase (eNAMPT), genotype-phenotype, luciferase reporter

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