EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy.

Sila Algül,Maike Schuldt,Emmy Manders, Valentijn Jansen,Saskia Schlossarek,Richard de Goeij-de Haas,Alex A Henneman,Sander R Piersma,Connie R Jimenez,Michelle Michels,Lucie Carrier,Michiel Helmes,Jolanda van der Velden,Diederik W D Kuster

Circulation research（2023）

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摘要

We showed the feasibility of screening for functional modulators of cardiomyocyte relaxation and contraction, parameters that we observed to be modulated by kinases involved in EGFR/IGF1R, Akt, cell cycle signaling, and FoxO (forkhead box class O) signaling, respectively. Integrating the screening data with phosphoproteomics analysis in HCM patient tissue indicated that inhibition of EGFR/IGF1R signaling is a promising target for treating impaired relaxation in HCM.

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