Rig-i agonist slr10 promotes macrophage m1 polarization during influenza virus infection

Jordan Metcalf,Wei Zhang,Jeremy Alexander,J. Leland Booth,Craig Miller,Chao Xu,Wenxin Wu

Frontiers in immunology（2023）

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摘要

Our data show that SLR10 administration in mice is protective for both NS and CS-exposed IAV-infected mice. Mechanistically, SLR10 treatment promoted M1 macrophage polarization in the lung during influenza infection. The protective effects by SLR10 may be a promising intervention for therapy for infections with viruses, particularly those with CS-enhanced susceptibility to adverse outcomes.

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关键词

influenza virus, RIG-I, agonist, SLR10, smoking, innate immunity, macrophage polarization

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