Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming.

Blanca Soler Palacios,Ricardo Villares,Pilar Lucas,José Miguel Rodríguez-Frade,Ana Cayuela,Jonathan G Piccirillo,Manuel Lombardía,David Delgado Gestoso,Miguel Fernández-García,Cristina Risco,Coral Barbas,Fernando Corrales,Carlos Oscar S Sorzano,Nuria Martínez-Martín,José Javier Conesa,Francisco J Iborra,Mario Mellado

Frontiers in immunology（2023）

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摘要

Our data demonstrate that GH likely serves a modulatory role in the metabolism of inflammatory macrophages and suggest that metabolic reprogramming of macrophages should be considered as a new target to intervene in inflammatory diseases.

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关键词

cryo-FIB/SEM,growth hormone,macrophages,metabolism,mitochondria

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