Predictors and Outcomes of Extracorporeal Membrane Oxygenation in COVID-19 Patients With ARDS: A Propensity-Matched Analysis of National Inpatient Sample

•Mechanically intubated COVID-19 ARDS patients placed on ECMO had no significant difference in mortality compared to patients without ECMO.•Mechanically intubated COVID-19 ARDS cohort placed on ECMO had higher rates of acute liver injury, blood loss anemia, and major bleeding. At the same time, there was no significant difference in AKI, cardiac arrest, acute MI, and blood transfusions.•Among all patients placed on ECMO, patients placed on VV-ECMO had lower odds of cardiac arrest, cardiogenic shock, and blood loss anemia.•VA-ECMO was associated with higher odds of cardiac arrest, cardiogenic shock, acute CHF, major bleeding, and Acute liver injury. However, the 2 groups had no difference in overall in-hospital mortality.•Resources utilization, including LOS and total cost, were significantly higher among COVID-19 patients placed on ECMO.