Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma.

Tomoharu Yamada,Naoto Fujiwara,Naoto Kubota,Yuki Matsushita,Takuma Nakatsuka,Shigeyuki Kurosaki,Tatsuya Minami,Ryosuke Tateishi,Akihiko Ichida,Junichi Arita,Kiyoshi Hasegawa,Kazuhiko Koike,Mitsuhiro Fujishiro,Hayato Nakagawa

Hepatology communications（2023）

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摘要

Besides its direct antitumor effects, lenvatinib recruited cytotoxic GZMK+CD8 T cells in intratumor stroma by CXCL9 from tumor-associated macrophages, suggesting that lenvatinib-treated HCC is in the so-called excluded condition that can diminish ICI efficacy.

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关键词

hepatocellular carcinoma,lenvatinib,cells

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