A rat model of metabolic syndrome-related heart failure with preserved ejection fraction phenotype: pathological alterations and possible molecular mechanisms.

Yujiao Shi,Chunqiu Liu,Chenguang Yang,Wenbo Qiao,Yongcheng Liu,Siyu Liu,GuoJu Dong

Frontiers in cardiovascular medicine（2023）

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摘要

The HFpEF rat replicates the pathology and clinical presentation of human HFpEF with MetS and may be a reliable preclinical model that helps elucidate HFpEF pathogenesis and develop effective treatment strategies.

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关键词

metabolic syndrome, heart failure with preserved ejection fraction, GDF-15, ICAM-1, VCAM-1, AKT/GSK-3 beta, TGF-beta 1/Smad

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