Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity.

Romain Garreau,Truong-Thanh Pham,Laurent Bourguignon,Aurélien Millet,François Parant,David Bussy,Marine Desevre,Victor Franchi,Tristan Ferry,Sylvain Goutelle

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

We identified common determinants of DIEP and myotoxicity in patients with BJI. Because the risk of AEs was associated with daptomycin exposure, daptomycin TDM and model-informed precision dosing may help optimize the efficacy and safety of daptomycin treatment in this setting. A target AUC24h range of 666 to 939 mg/h/L is suggested.

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muscular toxicity,pneumonia,daptomycin-induced

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