Acute inhibition of nicotinamide adenine dinucleotide phosphate oxidase in the commissural nucleus of the solitary tract reduces arterial pressure and renal sympathetic nerve activity in renovascular hypertension.

Stefanne M Marques,Mariana R Melo,Daniel B Zoccal,José V Menani,Débora S A Colombari,Marcos L Ferreira-Neto, Carlos H Xavier,Eduardo Colombari,Gustavo R Pedrino

Journal of hypertension（2023）

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摘要

These results demonstrate that the formation of ROS in the commNTS is important to maintain sympathoexcitation and hypertension in 2K1C rats and suggest that NADPH oxidase in the commNTS could be a potential target for therapeutics in renovascular hypertension.

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commissural nucleus of the solitary tract, nicotinamide adenine dinucleotide phosphate oxidase inhibitor, neural control of blood pressure, reactive oxygen species, renal vascular resistance

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