Young-onset Rectal Cancer: Unique Tumoral Microbiome and Correlation with Response to Neoadjuvant Therapy.

Michael G White,Ashish Damania,Jumanah Alshenaifi,Pranoti Sahasrabhojane,Oliver Peacock,Jillian Losh,Matthew C Wong, Zuzana Lutter-Berkova,George J Chang,Andrew Futreal,Jennifer A Wargo,Nadim J Ajami,Scott Kopetz,Y Nancy You

Annals of surgery（2023）

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摘要

Microbial signatures were distinct between YORC and LORC. Failure to achieve an MPR was associated with oral bacteria in tumors. These findings urge furture studies to decipher correlative versus mechanistic associations but suggest a potential for microbial modulation to augment current treatments.

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