Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.

Claire E Pillsbury,Jodi Dougan,Jennifer L Rabe,Jairo A Fonseca,Chengjing Zhou,Alyssa N Evans,Hasan Abukharma,Ona Ichoku,Gloria Gonzalez-Flamenco,Sunita I Park,Ahmed Aljudi,Deborah DeRyckere,Sharon M Castellino,Sarwish Rafiq,Solomon Langermann,Linda N Liu,Curtis J Henry,Christopher C Porter

Cancer research communications（2023）

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摘要

We demonstrate that Sig15 is overexpressed in hematologic malignancies driven by NFκB, is required for immune evasion in a mouse model of leukemia, and, for the first time, that it circulates at high levels in the plasma of children with leukemia.

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关键词

lymphoblastic leukemia,acute lymphoblastic leukemia,adaptive immunity,b-cell

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