Dual inhibition of BTLA and PD-1 can enhance therapeutic efficacy of paclitaxel on intraperitoneally disseminated tumors.

Wei-Zen Sun,Han-Wei Lin,Wan-Yu Chen,Chung-Liang Chien,Yen-Ling Lai,Jung Chen,Yu-Li Chen,Wen-Fang Cheng

Journal for immunotherapy of cancer（2023）

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摘要

Dual blockade of BTLA on B cells and PD-1 on cytotoxic T cells may have clinical potential for enhancing the efficacy of PTX in the treatment of tumors with intraperitoneal spread, including epithelial ovarian carcinomas.

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关键词

B-Lymphocytes, CD8-Positive T-Lymphocytes, Combined Modality Therapy, Immune Checkpoint Inhibitors, Immunomodulation

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