Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.

Minzhe Guo,Kathryn A Wikenheiser-Brokamp,Joseph A Kitzmiller, Cheng Jiang,Guolun Wang,Allen Wang,Sebastian Preissl,Xiaomeng Hou,Justin Buchanan,Justyna A Karolak,Yifei Miao,David B Frank,William J Zacharias,Xin Sun,Yan Xu,Mingxia Gu,Paweł Stankiewicz,Vladimir V Kalinichenko,Jennifer A Wambach,Jeffrey A Whitsett

American journal of respiratory and critical care medicine（2023）

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摘要

Distinct gene regulatory networks were identified in subsets of pulmonary endothelial and fibroblast progenitors, providing both cellular and molecular targets for development of therapies for ACDMPV and other diffuse lung diseases of infancy.

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关键词

alveolar capillary dysplasia, FOXF1, pulmonary microvasculature

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