Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity

Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antibiotics, further efforts are needed to develop new antimicrobial agents. Thiazoles conjugated with different heterocyclic ring systems are widely recognized as key frameworks for generating molecules with broad biological activities including antimicrobials specifically as anti-MRSA agents. Molecular hybridization, which tailors several heterocyclic pharmacophores into one molecular hybrid, represents a new avenue for the development of novel agents with improved biological applications. In this direction, many efforts were made to construct different heterocyclic systems substituted with thiazole nucleus and endowed with antibacterial potential because of its flexibility to approach various microbial targets. The current review article focuses on recent advances in thiazole-based hybrid molecules as anti-MRSA agents and discusses different orientations of structure-activity relationships (SARs). This collective data may provide a suitable platform for the design and construct of new thiazole-based small-molecule MRSA inhibitors.