Structural and microstructural thalamocortical network disruption in sporadic behavioural variant frontotemporal dementia

David Jakabek,Brian D. Power,Nicola Spotorno,Matthew D. Macfarlane,Mark Walterfang,Dennis Velakoulis,Christer Nilsson,Maria Landqvist Waldö,Jimmy Lätt,Markus Nilsson,Danielle van Westen,Olof Lindberg,Jeffrey C.L. Looi,Alexander F. Santillo

NeuroImage: Clinical（2023）

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摘要

•Multimodal analysis of sporadic behavioural variant frontotemporal dementia.•Simultaneous analysis of cortical thickness, diffusion metrics, and thalamic morphology.•Bilateral thalamic atrophy and reduced thalamic mean diffusivity in bvFTD.•Disease severity more associated with altered thalamic projections.

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关键词

frontotemporal dementia,microstructural thalamocortical network disruption

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