Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γΔ5 mice drives acute liver injury

Lauren G. Poole,Lauren R. Schmitt,Anthony Schulte,Dafna J. Groeneveld,Holly M. Cline,Yaqiu Sang,Woosuk S. Hur,Alisa S. Wolberg,Matthew J. Flick,Kirk C. Hansen,James P. Luyendyk

Journal of Thrombosis and Haemostasis（2023）

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摘要

•Mutant fibrinogen-γΔ5 (FibγΔ5) lacks the γ-chain C-terminal integrin αIIBβ3 binding domain.•The role of this domain in acetaminophen-induced liver injury is unknown.•FibγΔ5 lacks lysine 406 required for γ-γ dimer formation and forms altered cross-links.•Altered fibrin(ogen) cross-linking in FibγΔ5 mice is associated with elevated acute liver injury.

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关键词

acute liver injury,cross-linking

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