Bone targeting miR-26a loaded exosome-mimetics for bone regeneration therapy by activating Wnt signaling pathway

Liuzhi Hao, Shuwen Huang,Tongling Huang,Dan Yi,Chenmin Wang,Lixin Cheng,Min Guan,Jun Wu,Di Chen,Haobo Pan,William W. Lu,Xiaoli Zhao

Chemical Engineering Journal（2023）

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摘要

•Asp8 modification significantly increases targeting ability of EMs.•EM/miR-26a shows enhanced synergetic effects for bone regeneration.•Asp8-EM/miR-26a shows good biocompatibility in vitro and in vivo.•Asp8-EM/miR-26a promotes bone regeneration in bone defect and osteoporosis models.

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关键词

MSCs, Exosomes, miR-26a, Osteoporosis, Bone targeting, Bone regeneration

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