Meningeal lymphatics restoration and neurovascular protection synergistically improve traumatic brain injury treatment

Chemical Engineering Journal(2023)

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摘要
•Meningeal lymphatics hyperplasia but drainage decrease in open-skull TBI mouse model.•An GelMA-vECM hydrogel with sustained co-delivery of VEGF-C 156S and EVs for TBI.•This hydrogel enhanced lymphatic drainage and provided neurovascular protection for TBI.•The motor function was improved following TBI after this novel invasive treatment.
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关键词
traumatic brain injury treatment,neurovascular protection,brain injury,meningeal
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