Mediating Effects of Neural Targets on Depression, Weight, and Anxiety Outcomes of an Integrated Collaborative Care Intervention: The ENGAGE-2 Mechanistic Pilot Randomized Clinical Trial

Nan Lv,Olusola A. Ajilore,Lan Xiao,Elizabeth M. Venditti,Philip W. Lavori,Ben S. Gerber,Mark B. Snowden,Nancy E. Wittels,Corina R. Ronneberg,Patrick Stetz,Amruta Barve,Rohit Shrestha,Sushanth Dosala,Vikas Kumar, Tessa L. Eckley, Andrea N. Goldstein-Piekarski,Joshua M. Smyth,Lisa G. Rosas,Thomas Kannampallil,John Zulueta

Biological Psychiatry Global Open Science（2023）

引用 6|浏览16

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摘要

Compared with usual care, the study intervention led to significantly improved depression but not weight loss, and the results on neural targets were null for both outcomes. The significant intervention effect on anxiety might be mediated through changes in the cognitive control circuit, but this warrants replication.

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关键词

Anxiety,Cognitive control,Depression,Functional neuroimaging,Negative affect,Obesity

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