Development of Chimeric Hepatitis B (HBV) – Norovirus (NoV) P particle as candidate vaccine against Hepatitis B and norovirus infection

Ernawati Arifin Giri-Rachman,Marselina Irasonia Tan,Ashwin Ramesh, Putri Ayu Fajar, Annisa Nurul Ilmi,Debbie Sofie Retnoningrum,Rukman Hertadi, Apriliani Irawan, Gladys Emmanuella Putri Wojciechowska,Lijuan Yuan

Vaccine: X（2023）

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摘要

In summary, the chimeric HBV-HuNoV P particle vaccine given intranasally was safe and induced strong cellular and humoral immune responses in Gn pig. Modifications to the vaccine structure and dosage need to be evaluated in future studies to further enhance immunogenicity and induce more balanced humoral and cellular responses.

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Hepatitis B virus,Norovirus,Intranasal vaccination,Dual vaccine,Immunological response

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