Apolipoprotein E deficiency potentiates macrophage against Staphylococcus aureus in mice with osteomyelitis via regulating cholesterol metabolism.

Mincheng Lu,Ruiyi He, Chao Li,Zixian Liu,Yuhui Chen,Bingsheng Yang,Xianrong Zhang,Bin Yu

Frontiers in Cellular and Infection Microbiology（2023）

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摘要

We identified a previously unrecognized role of ApoE in osteomyelitis from the perspective of metabolic reprogramming. Hence, during treating osteomyelitis, considering cholesterol metabolism as a potential therapeutic target presents a new research direction.

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关键词

Apolipoprotein E,Staphylococcus aureus,osteomyelitis,infection,cholesterol metabolism,macrophages

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