Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.

Íngrid Martí-Pàmies,Robrecht Thoonen,Michael Morley,Lauren Graves, Jesus Tamez, Alex Caplan,Kendra McDaid,Vincent Yao,Allyson Hindle,Robert E Gerszten,Laurie A Farrell, Li Li,Yu-Hua Tseng,Gerson Profeta,Emmanuel S Buys,Donald B Bloch,Marielle Scherrer-Crosbie

Circulation research（2023）

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摘要

The results of this study suggest a cardioprotective role of BAT and BMP3b, a protein secreted by BAT, in a model of I/R injury. Interventions increasing BMP3b levels or targeting Smad 1/5 may represent novel therapeutic approaches to decrease myocardial damage in I/R injury.

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关键词

heart failure, mice, myocardium, reperfusion, uncoupling protein 1

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