ent -Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice.

Aaron Gochman,Tri Q Do,Kyungsoo Kim,Jacob A Schwarz, Madelaine P Thorpe,Daniel J Blackwell,Abigail N Smith,Wendell S Akers,Razvan L Cornea,Derek R Laver,Jeffrey N Johnston,Bjorn C Knollmann

bioRxiv : the preprint server for biology（2023）

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摘要

The cardiac ryanodine receptor (RyR2) is an untapped target in the stagnant field of antiarrhythmic drug development. We have confirmed RyR2 as an antiarrhythmic target in a mouse model of sudden cardiac death and shown the therapeutic efficacy of a second enantiomeric natural product.

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