Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses.

Fernando B Vergara-Hernandez,Brian D Nielsen,Jack J Kottwitz, Char L Panek,Cara I Robison, Brittany L Paris,Thomas H Welsh,Amanda N Bradbery,Jessica L Leatherwood,Aimee C Colbath

American journal of veterinary research（2023）

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摘要

The pharmacokinetic parameters and PPB of CLO in juvenile sheep were similar to those previously reported in horses. The results suggest that juvenile sheep can be utilized as an animal model for studying the potential risks and/or benefits of bisphosphonate use in juvenile horses.

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clodronate disodium,pharmacokinetics,single dose,horses

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