N-acetyldopamine derivatives from the egg cases of the insect Tenodera sinensis Saussure with COX-2 inhibitory activity

Mantidisamides A–D (1–4), four new N-acetyldopamine derivatives were isolated from the egg cases of Tenodera sinensis Saussure. Structures of the isolated compounds were confirmed by spectroscopic and computational methods. In particular, compound 4 is an unusual adduct composed of a N-acetyldopamine and a 4-quinolone moiety. Besides, 4 is a racemic mixture submitted to chiral HPLC to afford the enantiomers 4a and 4b. Biological activities of COX-2 inhibition and anti-renal fibrosis toward all the new compounds were evaluated.