Investigating the SLIT-ROBO signaling pathway in cholangiocarcinoma

Introduction Cholangiocarcinoma(CCA) is a rare but highly aggressive malignancy of the bile duct with inadequate therapy options and poor prognosis. A recent study identified genetic alterations in SLIT/ROBO pathway exclusively in the invasive form of CCA. The SLIT/ROBO pathway acts as axon-guidance-cues during neuronal development, it additionally orchestrates multiple processes in organ development, like cellular growth, attachment, and motility. The aim of this project is to functionally characterize the SLIT/ROBO signaling pathway in CCA.