Time-variable strain and stress rates induced by Holocene glacial isostatic adjustment in continental interiors

•Large-scale non-tectonic processes, (e.g., ice loading) may induce time-variable deformation across wide areas, beyond the directly loaded region.•While integrated strain (and stress) may remain low, instantaneous rates can be larger than background tectonic rates.•Non-tectonic modulation of the seismic cycle may result in sporadic seismicity on slow intraplate faults.