The APOE-TOMM40 Humanized Mouse Model: Characterization of Age, Sex, and PolyT Variant Effects on Gene Expression.

William K Gottschalk, Scott Mahon,Dellila Hodgson,Julio Barrera, Delaney Hill,Angela Wei, Manish Kumar,Kathy Dai,Lauren Anderson,Mirta Mihovilovic,Michael W Lutz,Ornit Chiba-Falek

Journal of Alzheimer's disease : JAD（2023）

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摘要

The model offers new opportunities for basic science, translational, and preclinical drug discovery studies focused on the APOE genomic region in relation to LOAD and other conditions in adulthood.

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关键词

humanized mouse model,gene expression,polyt variant effects,mouse model,apoe-tomm

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