Resistance of hypervirulent Klebsiella pneumoniae to cathepsin B-mediated pyroptosis in murine macrophages.

Jin Kyung Kim, Hui-Jung Jung,Miri Hyun,Ji Yeon Lee,Jong-Hwan Park,Seong-Il Suh,Won-Ki Baek,Hyun Ah Kim

Frontiers in immunology（2023）

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摘要

HvKp infection resulted in different levels of pyroptosis via the activation of cathepsin B-NLRP3-caspase-1 in murine macrophages. Therefore, the manipulation of pyroptotic cell death is a potential target for host response during hvKp infection in macrophages.

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关键词

hypervirulent, Klebsiella pneumoniae, macrophages, pyroptosis, cathepsin B

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