Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system.

Chunmei Xu, Jun Zhu, Guangyuan Gong,Li Guo, Ye Zhang,Ziyue Zhang, Chunlan Ma

Clinical and experimental hypertension (New York, N.Y. : 1993)（2023）

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摘要

Excessive salt intake activates NLRP3-dependent inflammation and oxidative stress and increased ATR expression and function in the PVN. Bilateral PVN infusion of anthocyanin lowers peripheral sympathetic nerve activity and blood pressure in rats with salt-induced hypertension by improvement of expression and function of ATR in the PVN through inhibiting NLRP3 related inflammatory and oxidative stress.

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关键词

Anthocyanin, salt-induced hypertension, NLRP3, sympathetic nerve activity, paraventricular nucleus, >

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