Long-term PPI treatment is a risk factor for acute-on-chronic liver failure in patients with advanced cirrhosis: a propensity score matched analysis

Introduction Identification of risk factors for acute-on-chronic liver failure (ACLF) is of major importance, since ACLF is a fatal complication of cirrhosis. While a number of studies have reported an association of proton pump inhibitor (PPI) treatment with complications of cirrhosis , the impact of PPI treatment on the risk of ACLF is unclear. Therefore, the present study aimed to investigate if PPI treatment affects ACLF development in patients with cirrhosis.