Pioneer factor FOXA2 is essential for maintaining the urea cycle in acute liver failure

Rilu Feng, Rui Li, Chenhao Tong,Tong Lin,Xiaofeng Li,Hui Liu,Chen Shao,Kejia Kan,Carsten Sticht,Yujia Li,Qianqian Wang,Stefan Munker, Hanno Nieß,Roman Liebe,Christoph Meyer, Shanshan Wang,Matthias P. Ebert,Steven Dooley,Huiguo Ding,Hua Wang,Honglei Weng

Zeitschrift Fur Gastroenterologie（2023）

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摘要

Background and Aims Disruption of the urea cycle results in hyperammonemia and thus causes hepatic encephalopathy (HE), a lethal complication of acute liver failure (ALF). A complete urea cycle requires six enzymes, including the rate-limiting enzyme carbamoyl phosphate synthetase I (CPS1). To date, the detailed regulation of CPS1 transcription in order to maintain urea cycle in ALF remains largely unknown.

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urea cycle,liver

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