Mri analysis of prostate morphometry and periprostatic anatomical relationships before and after partial high-intensity focused ultrasound treatment of localized prostate cancer.

You have accessJournal of UrologyCME1 Apr 2023MP73-13 MRI ANALYSIS OF PROSTATE MORPHOMETRY AND PERIPROSTATIC ANATOMICAL RELATIONSHIPS BEFORE AND AFTER PARTIAL HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT OF LOCALIZED PROSTATE CANCER. Denis Seguier, Srinath Kotarmarti, Zoe Michael, Rajan Gupta, Cary Robertson, Thomas Polascik, Jonathan Olivier, and Arnauld Villers Denis SeguierDenis Seguier More articles by this author , Srinath KotarmartiSrinath Kotarmarti More articles by this author , Zoe MichaelZoe Michael More articles by this author , Rajan GuptaRajan Gupta More articles by this author , Cary RobertsonCary Robertson More articles by this author , Thomas PolascikThomas Polascik More articles by this author , Jonathan OlivierJonathan Olivier More articles by this author , and Arnauld VillersArnauld Villers More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003341.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Little is known regarding anatomical changes to peri-prostatic tissues after focal high intensity focused ultrasound (fHIFU) for localized prostate cancer. We sought to provide a novel approach to assess prostato-pelvic anatomical morphometric magnetic resonance imaging (MRI) changes post- fHIFU. METHODS: 38 patients (Pts) over two institutions (Lille University Hospital and Duke University Hospital) undergoing fHIFU with pre-and post-treatment (Pre-/Post-Tx) (≥6 months) MRI were included. Pre- and post-TX. MRIs were assessed for prostate and treated region volume. Distances to pubic bone and rectum were measured to account for the post-Tx periprostatic changes. Two subgroups were also identified, those with recurrence (positive biopsy and/or subsequent whole gland Tx) and those recurrence-free. Specific MRI features were also described within those two groups. RESULTS: The median treated-lobe volume was of 16.8 ml (IQR 10.6-21.5) on pre-Tx MRI and of 10.2 ml on post-Tx MRI (IQR 7.2-14.8). Comparison on pre-Tx MRI vs. post-Tx MRI showed a significant difference (p<0.01). The median percentage reduction of treated lobe volume for the entire cohort was 28.5% (IQR: 17-47). No significant difference was identified between the non-recurring group and the recurring group for prostate volume and treated lobe-volume both at pre- and post-Tx. Analysis of prostato-rectal measurements was conducted in 17 Pts. The mean value of the median prostato-rectal distance was 2 mm (SD 1) in pre-Tx and 1.97 mm (SD 1.1) in post-Tx. We noted no significant difference in either the pre-Tx or post-Tx configuration (p=0.78 and p=0.1 respectively) between the groups of recurring vs. non-recurring Pts. 13 Pts were qualitatively classified as presenting an aspect of loss of symmetry in the prostato-rectal space on post-Tx MRI. No significative difference existed between the recurring and non-recurring group for this parameter. CONCLUSIONS: With this study, we described a novel standardized method of morphometric alteration post-fHIFU. This preliminary work incite further studies to assess the clinical significance and implications of these results in a larger prospective cohort. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1040 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Denis Seguier More articles by this author Srinath Kotarmarti More articles by this author Zoe Michael More articles by this author Rajan Gupta More articles by this author Cary Robertson More articles by this author Thomas Polascik More articles by this author Jonathan Olivier More articles by this author Arnauld Villers More articles by this author Expand All Advertisement PDF downloadLoading ...