The Safety and Efficacy of Ultrasound-Accelerated-Catheter-Directedthrombolysis with Urokinase in Patients with Intermediate-High Risk Pulmonary Embolism

Background: Ultrasound-accelerated-thrombolysis (USAT) represent a safe and effective therapeutic modality in patients with intermediate-tohigh risk pulmonary embolism. The tested thrombolytic agent in all studies investigating USAT in PE patients is alteplase (Actilyse). Actually, there is a lack of supply of alteplase (alteplase®, Boehringer Ingelheim) in Europe.