Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

Jvfei Wang,J Zhao,C Yan, Chen-Xi Xi,C Wu,J Zhao,F Li,Y Ding,R Zhang,S Qi,X Li,C Liu, Wenlong Hou, H Chen,Y Wang,D Wu,K Chen,H Jiang,H Huang, Huiting Liu

Yearbook of pediatric endocrinology（2022）

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摘要

Brief Summary: In preclinical models and a phase 1 trial, a powerful new lipid small molecule was shown to act through a mechanism distinct from those of known hypolipidemic agents. Targeting HNF-1α may be a new therapeutic strategy.

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small compound,lipid-lowering

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