Mp15-16 single dose antibiotics at the time of transperineal prostate biopsy are equivalent to outpatient antibiotic prophylaxis in preventing infection

You have accessJournal of UrologyCME1 Apr 2023MP15-16 SINGLE DOSE ANTIBIOTICS AT THE TIME OF TRANSPERINEAL PROSTATE BIOPSY ARE EQUIVALENT TO OUTPATIENT ANTIBIOTIC PROPHYLAXIS IN PREVENTING INFECTION Maxwell Sandberg, Wyatt Whitman, Janmejay Hingu, Parth Thakker, Caleb Bercu, Anita Rong, Jacob Greenberg, Ronald Davis, Ashok Hemal, and Matvey Tsivian Maxwell SandbergMaxwell Sandberg More articles by this author , Wyatt WhitmanWyatt Whitman More articles by this author , Janmejay HinguJanmejay Hingu More articles by this author , Parth ThakkerParth Thakker More articles by this author , Caleb BercuCaleb Bercu More articles by this author , Anita RongAnita Rong More articles by this author , Jacob GreenbergJacob Greenberg More articles by this author , Ronald DavisRonald Davis More articles by this author , Ashok HemalAshok Hemal More articles by this author , and Matvey TsivianMatvey Tsivian More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003235.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There has been a trend towards transperineal (TP) prostate biopsy over transrectal (TR) due to a reduced rate of infection. In response, there is now an ongoing debate as to the need for prophylactic antibiotics during TP biopsy. The objective of this study was to argue for the non-inferiority of single-dose antibiotics at the time of biopsy to outpatient antibiotics in preventing infection, regardless of antibiotic class chosen. METHODS: Biopsies were performed using TP technique under TR ultrasound guidance with anesthesia. All patients from 2012-present who underwent TP biopsy were identified and retrospectively chart reviewed. Infection was defined as at least one of the following: fever (≥38.3 °C) or positive urine culture (>10^5 CFU) within 72 hours post-biopsy. Patients were divided into 2 groups, those who received antibiotics at the time of biopsy along with outpatient antibiotics either before/after biopsy (group 1) and those who only received intraoperative antibiotics at the time of biopsy (group 2). Antibiotic choice and duration were at the discretion of the treating physician. Pearson’s Chi Squared was run to evaluate the difference in infection rate between the 2 groups. Fisher’s exact test evaluated the relationship between type of antibiotic and infection rate. RESULTS: A total of 767 biopsies were included in the study. Group 1 had 327 patients and group 2 had 440 patients. Infection rate post-TP biopsy was 1.97% (N=15). The infection rate for group 1 was 1.83% (N=6) and 2.05% (N=9) in group 2. No significant difference in infection rate existed between group 1 and group 2 (p=0.835). Secondary analysis was performed to evaluate infection rates based on antibiotic agent. TP biopsies with multiple antibiotics used at the same time were excluded from analysis. The type of antibiotic administered did not change infection rates within group 1 (p>0.99), group 2 (p=0.673), or between groups 1 and 2 (p>0.99). CONCLUSIONS: Based on our data, it appears that single dose antibiotics at the time of TP prostate biopsy are equivalent to outpatient antibiotic prophylaxis in preventing infection. Further, the class of antibiotic does not seem to affect infection rates. Given the overall low rate of infection, antibiotic regimens should be further evaluated for their utility. Source of Funding: N/A © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e198 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Maxwell Sandberg More articles by this author Wyatt Whitman More articles by this author Janmejay Hingu More articles by this author Parth Thakker More articles by this author Caleb Bercu More articles by this author Anita Rong More articles by this author Jacob Greenberg More articles by this author Ronald Davis More articles by this author Ashok Hemal More articles by this author Matvey Tsivian More articles by this author Expand All Advertisement PDF downloadLoading ...