Mp50-04 overall survival in penile cancer: analysis of a large contemporary cohort treated at a tertiary referral centre

You have accessJournal of UrologyCME1 Apr 2023MP50-04 OVERALL SURVIVAL IN PENILE CANCER: ANALYSIS OF A LARGE CONTEMPORARY COHORT TREATED AT A TERTIARY REFERRAL CENTRE James Churchill, Ashwin Sachdeva, Craig Jones, Allaudin Issa, Christian Fankhauser, Andrew Hudson, Anna Tran, Pedro Oliveira, Helen Johnson, Maurice Lau, Arie Parnham, and Vijay Sangar James ChurchillJames Churchill More articles by this author , Ashwin SachdevaAshwin Sachdeva More articles by this author , Craig JonesCraig Jones More articles by this author , Allaudin IssaAllaudin Issa More articles by this author , Christian FankhauserChristian Fankhauser More articles by this author , Andrew HudsonAndrew Hudson More articles by this author , Anna TranAnna Tran More articles by this author , Pedro OliveiraPedro Oliveira More articles by this author , Helen JohnsonHelen Johnson More articles by this author , Maurice LauMaurice Lau More articles by this author , Arie ParnhamArie Parnham More articles by this author , and Vijay SangarVijay Sangar More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003298.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Penile squamous cell carcinoma (PSCC) is rare and overall survival (OS) in metastatic disease remains poor. This study examines the OS, classified by TNM stage, in a large contemporary cohort of PSCC patients managed at a tertiary referral centre. METHODS: We analysed retrospective data from a prospectively maintained database for patients with PSCC treated between 2003 and 2022. We excluded clinically node-negative (cN0) patients who did not undergo invasive nodal staging (pNX). TNM stage was defined by histopathology (AJCC version 8) except where clinical/radiological findings of fixed inguinal nodes (cN3), pelvic lymphadenopathy (cN3) or distant metastatic disease (M1) were present. All patients were treated according to local guidelines. The primary outcome of OS (time from definitive primary surgery to death, censored for last follow-up) was analysed using the Kaplan-Meier method and log rank test. Multivariate Cox regression analysis for age, p16 status, TNM-stage and grade was performed. Audit approval was obtained from the host clinical governance committee. RESULTS: We identified 634 eligible patients. Baseline characteristics were similar in each group, with median age 64 years (range 26-94) and median follow-up 55 months (range 0-187). We describe OS (Figure 1) and risk of death by N and M stage, after multivariate analysis (Table 1). CONCLUSIONS: We demonstrate the contemporary OS outcomes of a large cohort of penile cancer patients receiving standard of care treatment at a tertiary referral centre, with significant OS differences by N and M stage. Our data confirm the poor survival outcomes of patients with N3 and M1 disease and these groups should be the target for developing novel management strategies. Conversely, patients with N1 and N2 disease have significantly longer survival, reinforcing the need for predictive biomarkers to help refine patient selection for optimal management. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e686 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information James Churchill More articles by this author Ashwin Sachdeva More articles by this author Craig Jones More articles by this author Allaudin Issa More articles by this author Christian Fankhauser More articles by this author Andrew Hudson More articles by this author Anna Tran More articles by this author Pedro Oliveira More articles by this author Helen Johnson More articles by this author Maurice Lau More articles by this author Arie Parnham More articles by this author Vijay Sangar More articles by this author Expand All Advertisement PDF downloadLoading ...