Mp17-18 prostate cancer genetic alterations in hispanic men

You have accessJournal of UrologyCME1 Apr 2023MP17-18 PROSTATE CANCER GENETIC ALTERATIONS IN HISPANIC MEN Camilo Arenas-Gallo, Stephen Rhodes, Jorge A. Garcia, Lina Posada, Ilon Weinstein, Megan Prunty, Patrick Lewicki, Aaron Brant, Spyridon P. Basourakos, Christopher E. Barbieri, Fredrick R. Schumacher, and Jonathan E. Shoag Camilo Arenas-GalloCamilo Arenas-Gallo More articles by this author , Stephen RhodesStephen Rhodes More articles by this author , Jorge A. GarciaJorge A. Garcia More articles by this author , Lina PosadaLina Posada More articles by this author , Ilon WeinsteinIlon Weinstein More articles by this author , Megan PruntyMegan Prunty More articles by this author , Patrick LewickiPatrick Lewicki More articles by this author , Aaron BrantAaron Brant More articles by this author , Spyridon P. BasourakosSpyridon P. Basourakos More articles by this author , Christopher E. BarbieriChristopher E. Barbieri More articles by this author , Fredrick R. SchumacherFredrick R. Schumacher More articles by this author , and Jonathan E. ShoagJonathan E. Shoag More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003237.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer is the most common cancer among Hispanic men and a leading cause of cancer death in Hispanic countries. Differences in DNA alterations in prostate cancer among White, Black, and Asian men have been widely described. This is the first description of the DNA alterations frequency in primary and metastatic prostate cancer of Hispanic men. METHODS: We utilized the targeted next-generation sequencing tumor genomic profiles from men with prostate cancer who underwent clinical sequencing tests at academic medical centers (GENIE 11th), for a total of 4,169 patients. We used data from all institutions with the Ethnicity category available for Spanish/Hispanic, non-Hispanic White, and non-Hispanic Black men. Numbers of men by ethnicity and racial categories were analyzed via Fisher’s exact test. RESULTS: Our final cohort comprised 2,140 primary and 1,251 metastatic adenocarcinomas. Among primary cancer, TMPRSS2 alterations were less common in White men as compared with Hispanic men (32.80% vs 45.16%; p=0.017) and Black men (23.81% vs 45.16%; p=0.0009). FOXA1 alterations were present more common in Black men than Hispanic men (20.77% vs 9.20%; p=0.024). For metastatic disease, TP53 alterations were less common in White men as compared with Hispanic (44.01% vs 60.38%; p=0.023) or Black (29.36% vs 60.38%; p=<0.001) men. FOXA1 alterations occurred more frequently in White men than Hispanic men (18.85% vs 6.00%; p=0.022). No significant differences were noted in the prevalence of actionable alterations between races. As patient and tumor characteristics are unknown in this dataset, differences in these characteristics according to race were not considered in the analyses. CONCLUSIONS: There appear to be clear differences in the frequency of DNA alterations in primary and metastatic prostate cancer among Hispanic, white, and black men. Notably, we found no significant differences in the prevalence of actionable genetic alterations between the groups, suggesting that a significant number of Hispanic men could benefit from the development of targeted therapies. Source of Funding: J.E.S is supported by the Frederick J. and Theresa Dow Fund of the New York Community Trust, the Vinney Scholars Award, and a Damon Runyon Cancer Research Foundation Physician-Scientist Training Award. F.R.S. is supported by NCI CA2333216, CA043703, CA241956, and CA254566 © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e219 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Camilo Arenas-Gallo More articles by this author Stephen Rhodes More articles by this author Jorge A. Garcia More articles by this author Lina Posada More articles by this author Ilon Weinstein More articles by this author Megan Prunty More articles by this author Patrick Lewicki More articles by this author Aaron Brant More articles by this author Spyridon P. Basourakos More articles by this author Christopher E. Barbieri More articles by this author Fredrick R. Schumacher More articles by this author Jonathan E. Shoag More articles by this author Expand All Advertisement PDF downloadLoading ...