Understanding the Effect of Prescription Isodose in Single-Fraction Stereotactic Radiosurgery on Plan Quality and Clinical Outcomes for Solid Brain Metastases.

Matthew H Brown,Samuel R Marcrom,Mayank P Patel,Richard A Popple,Roman L Travis,Andrew M McDonald,Kristen O Riley,James M Markert,Christopher D Willey,Markus Bredel,John B Fiveash,Evan M Thomas

Neurosurgery（2023）

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摘要

The prescription isodose line had no impact on local tumor control or CNS toxicity. Penalizing radiosurgery hotspots resulted in worse radiosurgery plans with poorer gradient. Limiting maximum dose in gross tumor causes increased collateral exposure to surrounding tissue and should be avoided.

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