Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.

Dajana Grossmann, Nina Malburg,Hannes Glaß, Veronika Weeren, Verena Sondermann, Julia F Pfeiffer,Janine Petters,Jan Lukas,Philip Seibler,Christine Klein,Anne Grünewald,Andreas Hermann

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

Our results demonstrated how the endoplasmic reticulum and mitochondria work together to cope with calcium stress in wild-type neurons. In addition, our results suggests that PRKN deficiency affects the dynamics and composition of MERCSs differently from PINK1 deficiency, resulting in differentially affected calcium homeostasis. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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关键词

PINK1, Parkin, Parkinson ' s disease, mitochondria-ER contact sites, calcium

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