Seizures regulate the cation-Cl - cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission.

Our results indicate that seizure induction causes dysregulation of NKCC1 expression in GASH/Sal animals, which overlaps with changes in GABA release. These observations provide evidence for the critical role of NKCC1 in how seizures affect neuronal excitability, and support NKCC1 contribution to the development of secondary foci of epileptogenic activity.