Discovery and Mechanism of Novel 7-Aliphatic Amine Tryptanthrin Derivatives against Phytopathogenic Bacteria.

Rice bacterial leaf blight is a destructive bacterial disease caused by () that seriously threatens crop yields and their associated economic benefits. In this study, a series of improved dissolubility 7-aliphatic amine tryptanthrin derivatives was designed and synthesized, and their potency in antibacterial applications was investigated. Notably, compound exhibited excellent activity against , with an EC value of 2.55 μg/mL, compared with the positive control bismerthiazol (EC = 35.0 μg/mL) and thiodiazole copper (EC = 79.4 μg/mL). In vivo assays demonstrated that exhibited a significant protective effect on rice leaves. After exposure, the morphology of the bacteria was partially atrophied by SEM. Furthermore, increased the accumulation of intracellular reactive oxygen species, causing cell apoptosis and the formation of bacterial biofilms. All the results indicated that could be a potential agrochemical bactericide for controlling phytopathogenic bacteria.