Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease

•Lacosamide shows neuroprotective effects in a rat model of Parkinson's disease.•Lacosamide reduces neuroinflammation and oxidative stress in a rotenone-induced PD model.•Lacosamide improves motor function in PD as observed in the apomorphine-induced rotation test.•Lacosamide preserves dopaminergic neurons and enhances tyrosine hydroxylase immunofluorescence in the striatum.•Lacosamide holds promise as a neuroprotective agent in PD, necessitating further investigation into its mechanisms and clinical potential.