Novel Genetic Risk Variants and Clinical Predictors Associated With Primary Sclerosing Cholangitis in Patients With Ulcerative Colitis.

Ming-Hsi Wang,Jessica J Friton,Nancy Rebert,Kelly Monroe,Billy D Nix,Claudio Fiocchi,Laura E Raffals,Jonathan A Leighton,Shabana F Pasha,Michael F Picco,Rodney D Newberry,Jean-Paul Achkar,William A Faubion

Clinical and translational gastroenterology（2023）

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摘要

Three variants in HLA (6p21.3) region significantly distinguished patients with UC-PSC from patients with UC alone. Once further validated in an independent large cohort, our model could be used to identify patients with UC at risk of PSC, and it could also help guide disease management.

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